据报道，丙型肝炎病毒（HCV）感染与2型糖尿病（T2DM）相关。研究旨在阐明，在HCV流行地区甘油三酯（TG) 和胆固醇（CHOL）水平在抗-HCV阳性和2型糖尿病的联系中所起的作用。

研究人员分析了56，338位居民的数据，该数据来自台湾台南县一个以社区为基础的全面筛查项目。空腹血糖，抗-HCV状态，乙型肝炎表面抗原（HBsAg）状态，血小板计数，甘油三酯水平，胆固醇水平，年龄，性别，身体质量指数被列入分析中。多元回归分析被用来确定糖尿病的独立相关因素。

结果发现，年龄，肥胖，高胆固醇血症，高甘油三酯血症，血小板减少症，抗-HCV阳性和乙肝病毒表面抗原抗体阴性，是糖尿病常见的独立相关因素。在所有多重逻辑回归分析，用于确定2型糖尿病的独立相关因素的模型中，丙型肝炎病毒血清阳性只在包括高甘油三酯血症或高胆固醇血症的模型中被确定。当受试者分为高血脂组（胆固醇>200，或甘油三酯>150mg/dL；n=33，393）和非高血脂分组（胆固醇<200，甘油三酯<150mg/dL；n=22，945），抗-HCV阳性只有在非高血脂亚组被确定作为一个独立的因素。比值比为1.35，95%CI 1.17-1.55。

这项研究表明，HCV血清阳性个体有较高的2型糖尿病和非高脂血症的患病率。如果不考虑血脂水平，HCV血清阳性和2型糖尿病之间的联系并不存在。进一步的病理生理的研究是必要的。(生物谷Bioon.com)

JGHF：HCV血清阳性与糖尿病相关

DOI: 10.1111/j.1440-1746.2012.07212.xPMC:PMID:

Community-based cross-sectional study: The association of lipids with hepatitis C seropositivity and diabetes mellitus

Ju-Ling Liu1,†, Jing-Yi Chen2,†, Chao-Tung Chen3,†, Jing-Houng Wang4, Chih-Yun Lin4, Pao-Fei Chen4, Chao-Hung Hung4, Kwong-Ming Kee4,Chuan-Mo Lee4, Lin-San Tsai5, Shu-Chuan Chen5,Sheng-Che Lin5, Sheng-Nan Lu4

Background and Aims:  Hepatitis C virus (HCV) infection is reported to be associated with or to cause type 2 diabetes mellitus (T2DM). Our study aimed to elucidate the role of triglyceride (TG) and cholesterol (CHOL) levels in the association between anti-HCV seropositivity and T2DM in an HCV-endemic area. Methods:  We analyzed a computerized dataset of 56 338 residents from a community-based comprehensive screening program in Tainan County in southern Taiwan. Fasting glucose, anti-HCV status, hepatitis B surface antigen (HBsAg) status, platelet counts, TG levels, CHOL levels, age, gender, and body mass index were included in the analyses. Multivariate logistic analysis was used to identify factors independently associated with T2DM. Results:  Older age, being overweight, thrombocytopenia, hypertriglyceridemia, hypercholesterolemia, anti-HCV seropositivity, and HBsAg seronegativity were common factors independently associated with diabetes. Among all models of multiple logistic regression analysis used for identifying factors independently associated with T2DM, anti-HCV seropositivity was only identified in the models that included either hypertriglyceridemia or hypercholesterolemia. When subjects were divided into hyperlipidemia (CHOL, > 200 or TG, > 150 mg/dL; n = 33 393) or non-hyperlipidemia subgroups (CHOL, < 200 and TG, < 150 mg/dL; n = 22 945), anti-HCV seropositivity was identified as an independent factor only in the non-hyperlipidemia subgroup. The odds ratio was 1.35, with a 95% confidence interval of 1.17